Human Bone Marrow Stromal Cells

Bone marrow stromal cells bmscs contains a subset of skeletal stem cells sscs that are multipotent capable of forming cartilage bone hematopoiesis supportive stroma and marrow adipocytes.

Human bone marrow stromal cells.

Bone marrow is a semi solid tissue found within the spongy or cancellous portions of bones. Adult bone marrow also contains stromal stem cells which contribute to the regeneration of several tissues such as bone cartilage muscle ligament tendon adipose tissue and marrow stroma 9 human bmscs have been identified and characterized and it has been shown that they support hematopoietic progenitors and secrete a number of. In birds and mammals bone marrow is the primary site of new blood cell production or haematopoiesis. Cd2 t lymphocytes obtained from either the donor of bone marrow stromal cells bmscs or a third party were cultured in mixed lymphocyte reactions mlrs with either allogeneic dendritic cells dcs or peripheral blood lymphocytes pbls.

It is composed of hematopoietic cells marrow adipose tissue and supportive stromal cells in adult humans bone marrow is primarily located in the ribs vertebrae sternum and bones of the pelvis. Stromal cells are connective tissue cells of any organ for example in the uterine mucosa endometrium prostate bone marrow lymph node and the ovary they are cells that support the function of the parenchymal cells of that organ. The most common stromal cells include fibroblasts and pericytes the term stromal comes from latin stromat bed covering and ancient greek στρῶμα. Human bone marrow stromal cells cultured using the mesencult acf culture kit maintain multi lineage differentiation potential.